John Libbey Eurotext

European Journal of Dermatology

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Adult-onset infective dermatitis associated with HTLV-I. Clinical and immunopathological aspects of two cases Volume 16, issue 1, January-February 2006

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Authors
Department of Pathology, Hospital Universitário Prof. Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil, Internal Medicine, Hospital, Universitário Prof. Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil, Laboratory of Retrovirology, Hospital Universitário Prof. Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil

Infective dermatitis associated with HTLV-I (IDH) is a chronic, infected childhood eczema. Two adult-onset cases of IDH were studied, one of which was associated with HAM/TSP. The patients were submitted to dermatological, neurological and pathological examination. Immunohistochemical studies were made using CD3, CD4, CD8, CD20, CD79a, and CD57 antibodies. Cytotoxic granules were investigated using granzyme B, perforin, and TIA. The patients presented infected erythematous, scaly lesions with mild itching and a good response to sulfamethoxazole/ trimethoprim. A differential diagnosis with atopic dermatitis (AD) and seborrheic dermatitis (SD) was made, based on: the distinctive morphology and distribution of the lesions, presence of exudative and infected lesions, and mild pruritus. The inflammatory infiltrate was composed predominantly of CD8+ lymphocytes that did not present cytotoxic granules. We concluded that IDH can begin in adulthood and may be associated with HAM/TSP. The immunohistochemical findings were different from those observed in AD and SD.