Volume 93, supplement 4, Numéro hors-série, Avril 2006

Formation SFC

Éditorial (p.3)
Jacques Robert

From conventional chemotherapy to targeted therapies of cancer : mechanisms of oncogenesis at the molecular and cellular levels (p.5-16)
Jacques Robert

Growth factors of the EGF family and their receptors (p.17-24)
Pierre Hubert

The mitogen actived protein kinases (MAPK) pathway, a target for anticancer drugs (p.25-30)
Gilles Favre

PI3K and mTOR signalling pathways: perspectives for rapamycin and its derivatives as antineoplastic targeted therapies (p.31-40)
Chantal Dreyer, Sandrine Faivre, Eric Raymond

The cell division cycle and its regulation (p.41-53)
Laurent Meijer

Ubiquitin, proteasome and cancer (p.54-60)
Jean-Guy Delcros, Yannick Arlot-Bonnemains

Cell death induced by cytotoxic agents (p.61-70)
Éric Solary

Telomeres and telomerase as therapeutic targets in the treatment of cancer (p.71-82)
Ken André Olaussen, Laure Sabatier, Benjamin Besse, Jean-Charles Soria

Role of histone deacetylase inhibitors in antitumor therapy (p.83-7)
Maya Ameyar-Zazoua, Annick Harel-Bellan

Role of the Wnt pathway in oncogenesis (p.88-97)
Gilles L’Allemain

Cox2 and oncology: from bench to bedside (p.98-106)
Jean-Baptiste Méric, Jean-Philippe Spano

Mechanisms of action of recombinant monoclonal antibodies used in oncology (p.107-12)
Alicia Probst, Guillaume Cartron, Hervé Watier

Pharmacogenetics and pharmacogenomics (p.113-23)
Jacques Robert

DNA repair, a potential target for anticancer drug development (p.124-44)
Philippe Pourquier

p53 as a therapeutic target for the development of anticancer drugs (p.145-53)
Benjamin Pierre Bouchet, Claude Caron de Fromentel, Carlos María Galmarini, Alain Puisieux

Tumor angiogenesis (p.154-64)
Andréas Bikfalvi

Biology of cancer metastasis (p.165-74)
Marie-France Poupon

Éditorial

Le traitement des tumeurs stromales gastro-intestinales : introduction à un changement des pratiques en oncologie (p.155)
Jean-Yves Blay

Synthèse

Definition, recent data in pathology and molecular biology on gastrointestinal stromal tumors (GIST) (p.157-65)
Laurent Doucet

Surgery of primary and advanced gastrointestinal stromal tumors (GIST) in the imatinib era (p.167-72)
Delphine Rouquie, Sylvie Bonvalot

Medical treatment of localized and advanced GIST: therapeutic standards in 2006 (p.173-80)
Jérôme Fayette, Pierre Méeus, Isabelle Ray-Coquard, Dominique Ranchère, Philippe Thiesse, Anne-Valérie Decouvelaere, Marie-Pierre Sunyach, François Mithieux, Séverine Tabone-Eglinger, Sylvie Bonvalot, Jean-Yves Scoazec, Pierre Paul Bringuier, Jean-Michel Coindre, Binh Bui, Axel Le Cesne, Jean-Yves Blay

Multidisciplinary treatment of GIST (p.181-9)
Isabelle Ray-Coquard, Chadi Saba, Françoise Ducimetière, Cyril Confavreux, Fhadi Rustam, Pierre Méeus, Jean-François Brantus, Dominique Ranchère-Vince, Philippe Thiesse, Jérome Fayette, Jean-Yves Scoazec, Pierre-Paul Bringuier, Jean-Michel Coindre, Binh Bui, Sylvie Bonvalot, Jean-Yves Blay, Pierre Biron, Axel Le Cesne