John Libbey Eurotext

Bulletin du Cancer


Targeted therapies: last focus on EGF receptor inhibitors in breast cancer Volume 91, issue 4, Avril 2004

Laboratoire d’oncopharmacologie, Centre Antoine-Lacassagne, 33 avenue de Valombrose, 06189 Nice Cedex 2, Département de radiothérapie, Institut Jules-Bordet, Bruxelles, Belgique

EGF receptor is slightly expressed in breast cancer without any sufficiently impact on patient outcome. Nevertheless determination of EGFR level represents a certain interest in order to orientate a targeted therapy notably in the case of hormone therapy resistance. Based on preclinical findings, preliminary clinical study results confirms in vitro observations about the possibility to encompass the hormonotherapy or anti-HER2 resistance. But, future large clinical trials are necessary to redefine a new strategy to treat breast cancer patients.