John Libbey Eurotext

Bulletin du Cancer


Impact of radiotherapy on fertility in female patients Volume 96, issue 10, octobre 2009

Service d’oncologie radiothérapie, hôpital d’instruction des armées du Val-de-Grâce, Paris, France, Département de radiothérapie-oncologie, Institut Jules-Bordet, Bruxelles, Belgique, Service de chirurgie gynécologique et mammaire, hôpital de La Pitié-Salpêtrière, AP-HP, Paris, France, Service de curiethérapie, Institut Gustave-Roussy, Villejuif, France, Service d’oncologie médicale, hôpital de La Pitié-Salpêtrière, AP-HP, Paris, France

Although insufficiently documented, the impact of radiation therapy on fertility should not be neglected in female patients. Toxicity on reproductive function is dual and is characterized by both mechanistic deleterious effects on the genital tract and partial or complete loss of ovarian function. Moreover, gonadic toxicity may be increased by the concurrent use of chemotherapy or surgical procedure. In some circumstances, ovarian transposition may be justified for young patients. But no compromise may be accepted in terms of carcinologic results. At least, the effect of low-doses of irradiation has not been demonstrated for extra-pelvic radiotherapy.