John Libbey Eurotext

Bulletin du Cancer


Basaloid squamous cell carcinomas of the head and neck Volume 96, issue 10, octobre 2009


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Département d’oncologie-radiothérapie, Centre Antoine-Lacassagne, Université Nice - Sophia-Antipolis, IBDC CNRS UMR 6543, 33, avenue Valombrose, 06189 Nice Cedex 2, MD, PhD. Département d’anatomopathologie. Hôpital Européen Georges-Pompidou, 20-40 rue Leblanc, 75015 Paris, MD, Département d’anatomopathologie, University Medical Center of Grenoble, 38043 Grenoble Cedex 09, MD, Service d’ORL et chirurgie cervico-faciale, CHU Pellegrin, Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux Cedex, MD, Département d’anatomopathologie. CHU Pasteur, Inserm ERI-21/EA4319/Tumorothèque, CHU Nice UNSA BP 69, 06002 Nice Cedex 1, MD, Service d’ORL et chirurgie cervico-faciale, Centre Antoine-Lacassagne, Institut universitaire de la face et du cou, BP 69, 06002 Nice cedex 1, Service d’ORL et chirurgie cervico-faciale, Centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice Cedex 2, MD, Département de radiothérapie, Centre Georges-François-Leclerc, 1, rue du Professeur-Marion, 21079 Dijon Cedex, MD, PhD. Département d’oncologie, CHU Bichat-Beaujon (SIHC), Hôpital Beaujon, 100 boulevard du Général-Leclerc, 92118 Clichy, MD, PhD, Département d’anatomopathologie, Institut Curie, rue d’Ulm, Paris, MD, Service d’ORL et chirurgie cervico-faciale, CHU Tenon, rue de la Chine, 75020 Paris, MD, PhD, Clinique ORL, Pôle tête et cou et chirurgie réparatrice, Centre Médico-Universitaire de Grenoble, Inserm UJF/U823, Institut de recherche Albert-Bonniot, 38043 Grenoble Cedex 09

Basaloid squamous cell carcinomas (SCC) are a rare variant of SCC of the head and neck. Their histological characteristics have been described by Wain in 1986 and are reported in the 2005 WHO classification. A poorer prognosis of BSCC has been reported. Two recent case-control studies have shown a higher rate of distant metastases (15-40%, mean over 30%). Conversely, BSCC have similar or better locoregional control rates, a relatively good radiosensitivity and locoregional control. The role of chemotherapy in the neoadjuvant, concomitant or adjuvant setting needs to be redefined due to high metastatic failure rates; chest CT or PET CT are recommended at baseline and every 6-month during follow-up. Some subgroups of BSCC (oropharynx in particular) are more likely to be associated with oncogenic human papilloma virus HPV16. The determination of BSCC head and neck subgroups by HPV status is critical for the prognosis. The basaloid sub-type of squamous cell carcinomas owing to its particular behavior, should be taken into account while deciding the optimal therapeutic strategy.