John Libbey Eurotext

Hépato-Gastro & Oncologie Digestive


New direct biomarkers of alcohol consumption Volume 29, issue 4, April 2022


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1 Hôpital Huriez, CHU de Lille, Service des maladies de l’appareil digestif, Rue Michel Polonowski, 59000 Lille
2 CHU de Lille, Unité fonctionnelle de toxicologie, 59000 Lille
3 Hôpital Fontan 2, CHU Lille, Service addictologie, 1 rue André Verhaeghe, 59037 Lille
* Correspondance : S. Dharancy

The development of objective tests to characterize the mode of consumption, quantify the quantity of ethanol ingested daily and effectively detect disorders induced by alcohol is essential in the fields of treatment and research, but also in legal areas. Indirect biomarkers of alcohol consumption are linked to metabolic and/or biochemical modifications, do not allow assessing the extent of consumption, having a non-negligible latency time and many confounding factors in their interpretation. Direct markers, in particular, ethylglucuronide (EtG) and phosphatidylethanol (PEth) are the subject of growing interest in Hepatology, Toxicology and Addictology. The literature is convincing to conclude that they are very sensitive and specific biomarkers of alcohol consumption and that they offer a wide range of detection windows. They must nevertheless be used as catalysts for discussion with the patient on the alcohol problem.