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What are the causes of death after liver transplantation? Volume 31, issue 1, January 2024

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Authors
CHU Montpellier, Hôpital Saint-Éloi, Service d’hépato-gastroentérologie A, 80 avenue Augustin Fliche, 34090 Montpellier
* Correspondance : M. Meszaros

Liver transplantation has become the treatment of choice to increase survival and quality of life of patients with end-stage chronic liver disease, acute liver failure and other liver diseases including hepatocellular carcinoma without any other effective curative therapeutic option. Advances in immunosuppressive therapy, improved surgical expertise, and early diagnosis and management of complications after liver transplantation have led to a gradual improvement in survival rates, especially in the short and medium term, however the long-term survival rate, after 10 years, remains stable since two decades, around 60%. Long-term survivors are at increased risk of morbidity due to other than classic complications of transplantation such as graft dysfunction, rejection, or recurrence of liver disease. De novo malignancies, metabolic disorders, cardiovascular diseases and renal failure have emerged as causes of late death after liver transplantation. Long-term post-transplant care is complex and requires specialized and regular follow-up to detect, treat and prevent the above-mentioned complications.