Institut Curie, Université Versailles Saint-Quentin, Département d’Oncologie Médicale, 35 rue Dailly, 92210 Saint-Cloud
This article presents a summary of the key presentations in digestive oncology of the European Society For Medical Oncology (ESMO) conference held in Barcelona at the end of September 2019. Among them, an ancillary analysis of the IDEA France Phase III study confirmed that circulating tumor DNA is a major prognostic factor in localized colon cancers. In patients with metastatic colorectal cancer with BRAF V600E mutation, the BEACON phase III study demonstrated the superiority of the inhibition triplet encorafenib (anti-RAF)/binimetinib (anti-MEK)/cetuximab (anti-EGFR) compared to chemotherapy with FOLFIRI and cetuximab, making this triplet a new standard in the second line setting. In non-colorectal gastrointestinal cancers, nivolumab (anti-PD1) immunotherapy has been shown to be effective vs. second-line chemotherapy in advanced squamous cell carcinoma of the esophagus in the ATTRACTION-03 Phase III study. The ClarIDHy Phase III study has shown that ivosidenib, an inhibitor of the mutated form of IDH1, improves progression-free survival over placebo in patients with cholangiocarcinoma with IDH1 mutation. Ripretinib is the new fourth-line reference treatment for advanced gastrointestinal stromal tumors based on the results of the INVICTUS Phase III study, which showed superiority over placebo.
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