Solid tumors are rare events occurring after hematopoietic allogeneic or autologous stem cell transplantation. Main data on the incidence and risk factors for these secondary malignancies are summarized.
Following allogeneic bone marrow transplantation, an international survey involving nearly 20.000 patients describes the occurrence of
80 solid tumor cases. Relative to general population (2.7 cases expected) this observed 80 cases lead to a statistically significant increased incidence. Cumulative incidence of solid tumor at 10 and 15 years was 2.2 and 6.7%, respectively.
Concerning the risk of solid tumors after autologous stem cell transplantation, data are scarce but strongly suggest an increased risk, relative to the general population. Clearly, additional studies involving large number of patients are needed to study the incidence and risk factors of solid tumors occurring after autologous stem cell transplantation.