- Key words: immunotherapy, anti-idiotypic vaccination, GVL.
- Page(s) : 518-27
- Published in: 1998
Recent advances in immunology, concerning antigen presentation and lymphocyte activation, allow at present to consider new therapeutic strategies for cancer patients as vaccination or cellular therapy. Most of these therapies are based on the identification of tumor associated antigens and on the observation of a specific T lymphocyte response in these patients. However, a state of immune tolerance is observed in cancer patients, which seems to allow tumor growth. Thus, understanding of the implied mechanisms becomes important to propose an adapted immuno-intervention. These approaches also concern hematologic malignancies and vaccination trials have been conducted in patients with follicular lymphomas. Many studies of the anti-leukemic immune response are also performed, allowing to expect new therapeutic strategies in these patients.