John Libbey Eurotext



Recent acquisitions on functional properties of the p14/p19ARF tumor suppressor protein and its importance in oncohaematology Volume 8, issue 6, Novembre - Décembre 2002


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Laboratoire d'oncologie moléculaire, IBMIG, 40, avenue du Recteur-Pineau, 86022 Poitiers, France.

During the last few years, the ARF gene (p14ARF in man and p19ARF in mouse) has acquired a unique status in that sense that it is implicated in two regulatory pathways : ARF-mdm2-p53 pathway and another one, p53-independent, that, in view of numerous experimental data, could be pRB pathway. These facts are consistent with the high frequency of alterations of ARF in a number of tumors and also its increasing importance in molecular oncology. This review presents a state of art of ARF biology by underscoring a comprehensive approach of the mechanisms that explain its activity, the consequences of its inactivation and/or deregulation in tumors. The importance of ARF in onco-hematology is also examined in the light of recent results showing deregulation of the ARF-p53 pathway by a chimeric protein (AML1-ETO) generated by t(8;21) chromosome translocation in M2 acute myeloblastic leukemia.