Update of pernicious anemia Volume 15, issue 6, novembre-décembre 2009

Service de médecine interne, CHU Le Dantec, Dakar, Sénégal

Purpose. The aim of this study was to describe the present clinical characteristics of the pernicious anemia (PA). Method. It is a retrospective (2000-2007) study of 26 patients presenting an established cobalamin deficiency related to PA. Results. The median age of the patients was 51 years (24-79), the male/female ratio 0.73. The median delay of the diagnosis was 16 months (6-48). Various clinical manifestations, mainly neurological in 42.3%, cutaneous in 42,3% and gastric in 61,5 % were at least one hematological abnormalities in 100 %. Average serum vitamin B12 was very low in 84,6% (n = 22) of cases. Anti-intrinsic factor or anti-parietal gastric cells antibodies were found in all the cases. All the followed patients were successfully treated with intramuscular (n = 25) or oral crystalline cyanocobalamin (n = 1). Conclusions. PA may be responsible of various clinical manifestations or biological abnormalities; and oral crystalline cyanocobalamin treatment may be successful.