Induced pluripotent stem cells : from history to applications Volume 19, issue 1, Janvier-Février 2013


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Inserm U1009, université Paris Sud, institut Gustave-Roussy, Villejuif, France, Assistance publique des hôpitaux de Paris, hématologie biologique, université Paris-Est Créteil, hôpital Henri-Mondor, Créteil, France, Assistance publique des hôpitaux de Paris, service de biothérapie, hôpital La Pitié-Salpêtrière, Paris, France

Induced pluripotent stem cells were discovered at the end of 2006. They are derived from somatic cells and are functionally close to embryonic stem cells, i.e. characterized by self-renewal and pluripotency properties. They are offering new opportunities in fundamental research and in applied research such as disease modeling, pharmacology research and toxicology. In clinic, they could be used in cell and gene therapies.