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Genotoxic potential of nanomaterials: State of the research Volume 13, issue 2, Mars-Avril 2014

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EDF
Service des études médicales
45 rue Kléber
92309 Levallois-Perret cedex
France
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  • Key words: nanomaterials, tests, genotoxicity
  • DOI : 10.1684/ers.2014.0684
  • Page(s) : 113-22
  • Published in: 2014

The toxicity of nanomaterials, including their genotoxicity, is the object of several research projects across the world. Currently available data on their genotoxicity show high variability in study results as well as complexity associated with the use of the existing methods that makes it difficult to interpret and compare these results. Although some existing genotoxicity evaluation methods can be applied to nanomaterials, they require adaptation, to take the physicochemical specificities of nanomaterials into account. This report of published data in the field of nanogenotoxicology presents some possible mechanisms of this genotoxicity, an evaluation of the methods used in various studies, the factors that influence the results, and some recommendations to enable subsequent studies to control for these factors.