John Libbey Eurotext

Environnement, Risques & Santé

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Guidelines for derivation of toxicity reference values for carcinogens Volume 5, issue 3, Mai-Juin 2006

Authors
École d’application du service de santé des armées (EASSA), Îlot Val de Grâce, 1, Place Alphonse Laveran, 75001 Paris cedex 5, Agence française de sécurité sanitaire de l’environnement et du travail (Afsset), 253, avenue du Général Leclerc, 94701 Maisons-Alfort cedex, Institut national de la santé et de la recherche médicale (Inserm), ERI n o11 Faculté de médecine 9, avenue de la Forêt de Haye, 54505 Vandoeuvre-Les-Nancy cedex
  • Key words: carcinogens, environmental, chemicals, dose-response relationship, drugs, models, theoretical, chemicals, risk assessment, toxicological reference values
  • Page(s) : 181-9
  • Published in: 2006

The public is becoming increasingly aware of the risks associated with carcinogenic chemicals in the environment. While the carcinogenic potential of many substances is recognized, there may be several different quantitative toxicity reference values for a given chemical, or, on the contrary, none at all. This situation, which makes it difficult to perform accurate quantitative risk assessments, results from the absence of harmonization between international institutions that establish these reference values. Because there is currently no recognized method for developing such values in France, this article reviews the principal published methods for their development. Our goal is to describe the most important methodologic points to be considered in deriving or choosing toxicity reference values for carcinogenic agents.