John Libbey Eurotext

Late adult-onset epilepsy in a patient with hemimegalencephaly Volume 21, issue 2, April 2019


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Departments of Clinical Neurological Sciences (SAC, SMM), Medical Imaging (SMM), Medical Biophysics (SMM), Psychology (SMM), Western University, London, Canada
* Correspondence: Seth Climans Department of Clinical Neurological Sciences, Room B7-005, 339 Windermere Road, London, Ontario, N6A 5A5, Canada

Hemimegalencephaly is a malformation of cortical development that normally manifests in childhood with seizures and cognitive impairment. We present a case of hemimegalencephaly in a 55-year-old developmentally-normal woman who developed focal impaired awareness seizures with bilateral tonic-clonic spread. Her interictal EEG showed left-sided multifocal spikes, and ictal EEG showed seizures starting in the left hemisphere. Imaging showed hemimegalencephaly. This case may represent the oldest age for a first seizure in a patient with hemimegalencephaly.