John Libbey Eurotext

EEG source estimation in a rare patient with cold-induced reflex epilepsy Volume 22, issue 4, August 2020

Videos

  • EEG source estimation in a rare patient with cold-induced reflex epilepsy
  • EEG source estimation in a rare patient with cold-induced reflex epilepsy

Figures

  • Figure 1
  • Figure 2

Tables

Authors
1 Department of Geriatric Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China
2 Faculty of Information Technology, University of Jyväskylä, Jyväskylä, Finland
3 State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
4 School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China
5 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
6 Beijing Key Laboratory of Neuromodulation, Capital Medical University, Beijing, China
7 Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China
* Correspondence: Tapani Ristaniemi Mattilanniemi 2, P.O. Box 35, FI-40014, Jyväskylä, Finland Ruihua Zhang No. 82, Xinhua South Street, Tongzhou District, Beijing, 101149, China

Temperature-related reflex epilepsy most often takes the form of hot water epilepsy, but very rarely, reflex epilepsy is related to cold temperature. We report a 70-year-old male who had seizures triggered by cold sensations in the body. Four antiepileptic drugs were taken during the drug treatment, and oxcarbazepine was the most effective at stopping the seizures. We implemented clinical seizure induction and obtained EEG data from an interictal period and two complete ictal periods. Source estimation was performed to identify and map the primary sources involved in the seizures on the cortical level. We found that β rhythm appeared on the prefrontal lobes during the whole ictal period. The low-frequency slow δ and θ rhythms, especially the δ rhythm, appeared in the occipital lobe in the early ictal stage and propagated to the right temporal lobe in the mid-late ictal stage. The prefrontal lobe and right temporal lobe were mainly involved in the generation and propagation of the epileptic activities. This study provides a valuable reference for clinical drug therapy and provides insights into the characteristics of the brain activities involved in cold-induced reflex epilepsy. [Published with video sequences].