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Control groups in paediatric epilepsy research: do first-degree cousins show familial effects? Volume 19, issue 1, March 2017

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Authors
1 Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI
2 Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL
3 Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
* Correspondence: Bruce Hermann Department of Neurology, University of Wisconsin, 1685 Highland Avenue, Madison, WI 53705, USA

Aim

To determine whether first-degree cousins of children with idiopathic focal and genetic generalized epilepsies show any association across measures of cognition, behaviour, and brain structure. The presence/absence of associations addresses the question of whether and to what extent first-degree cousins may serve as unbiased controls in research addressing the cognitive, psychiatric, and neuroimaging features of paediatric epilepsies.