John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

Control groups in paediatric epilepsy research: do first-degree cousins show familial effects? Volume 19, numéro 1, March 2017

Illustrations

  • Figure 1
  • Figure 2
  • Figure 3

Tableaux

Auteurs
1 Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI
2 Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL
3 Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
* Correspondence: Bruce Hermann Department of Neurology, University of Wisconsin, 1685 Highland Avenue, Madison, WI 53705, USA
  • Mots-clés : cousin control, research design, cognition, behaviour, brain imaging, focal idiopathic epilepsy, genetic generalized epilepsy
  • DOI : 10.1684/epd.2017.0898
  • Page(s) : 49-58
  • Année de parution : 2017

Aim

To determine whether first-degree cousins of children with idiopathic focal and genetic generalized epilepsies show any association across measures of cognition, behaviour, and brain structure. The presence/absence of associations addresses the question of whether and to what extent first-degree cousins may serve as unbiased controls in research addressing the cognitive, psychiatric, and neuroimaging features of paediatric epilepsies.