John Libbey Eurotext

European Journal of Dermatology

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A case of locally-advanced Merkel cell carcinoma progressing with disseminated bone marrow metastases Volume 28, issue 4, July-August 2018

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Authors
1 Department of Medicine, Division of Hematology and Medical Oncology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA
2 Department of Medicine, Division of Hematology and Medical Oncology, Edward Hines Jr. VA Hospital, Hines, IL, USA
3 Department of Pathology, Edward Hines Jr. VA Hospital, Hines, IL, United States

Merkel cell carcinoma (MCC) is a rare, small-cell skin cancer arising from neuroendocrine cells [1]. Merkel cell polyomavirus (MCPyV) is present in up to 80% of MCC cases and may promote oncogenesis in immunosuppressed individuals [2]. Patients diagnosed with Stage III and IV MCC have an estimated five-year overall survival (OS) of 13-35% [3]. Advanced MCC with bone marrow metastases is associated with a dismal prognosis [4-7]. Here, we present a case of locally advanced MCC with disease progression [...]