John Libbey Eurotext

Annales de Biologie Clinique

Added value of hepcidin quantification for the diagnosis and follow-up of anemia-related diseases Volume 75, issue 1, Janvier-Février 2017

Figures

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Authors
Constance Delaby Groupe de travail « Intérêts cliniques du dosage de l’hepcidine » de la Société française de biologie clinique 7 8 9 *
1 Centre français des porphyries, Hôpitaux Universitaires Paris Nord Val de Seine site Louis Mourier, APHP, Colombes ; Inserm U1149, Centre de recherche sur l’inflammation, Paris, France
2 Lunam, Université d’Angers, Département anesthésie réanimation, CHU Angers, France
3 Laboratoire de biochimie, CHU Bicêtre AP-HP, Le Kremlin Bicêtre, France
4 Clinique Beau Soleil, Montpellier ; Labosud-Ocbiologie, Montpellier, France
5 Département d’hématologie biologique, Hôpital Saint Eloi, CHRU de Montpellier, Montpellier, France
6 Laboratoire de biochimie spécialisée - Hôpital Pontchaillou, CHU de Rennes, Rennes, France
7 Institut de médecine régénératrice et de biothérapies (IRMB)-Laboratoire de biochimie-protéomique clinique-CCBHM, Hôpital Saint Eloi, CHRU de Montpellier, Montpellier, France
8 Université de Montpellier, France
9 Inserm U1040, Montpellier, France
* Tirés à part
  • Key words: hepcidin, anemia, iron, inflammation
  • DOI : 10.1684/abc.2016.1208
  • Page(s) : 9-18
  • Published in: 2017

Iron homeostasis is based on a strict control of both intestinal iron absorption and iron recycling through reticulo-endothelial system. Hepcidin controls the iron fluxes in order to maintain sufficient iron levels for erythropoietic activities, hemoproteins synthesis or enzymes function, but also to limit its toxic accumulation throughout the body. Hepcidin expression is regulated by various stimuli: inflammation and iron stimulate the production of the peptide, while anemia, erythropoiesis and hypoxia repress its production. Regulation of hepcidin expression is not so simple in complex pathological situations such as hemolytic anemia, cancer or chronic inflammation. Serum hepcidin quantification in association with the diagnostic tests currently available is quite promising for the diagnosis or the follow-up of anemia in those conditions. This study is part of the working group « Clinical interests of hepcidin quantification » of the Société française de biologie clinique.