John Libbey Eurotext

Magnesium Research


The permeability of magnesium across the skin is enhanced by menthol cream Volume 32, issue 4, October-November-December 2019

  • [1] Scientific opinion on dietary reference values for magnesium. EFSA J. 2015;13:4186. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies)
  • [2] Rosanoff A., Weaver C.M., Rude R.K. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev. 2012;70:153-164.
  • [3] Guerrera M.P., Volpe S.L., Mao J.J. Therapeutic uses of magnesium. Am Fam Physician. 2009;80:157-162.
  • [4] Chandrasekaran N.C., Sanchez W.Y., Mohammed Y.H., Grice J.E., Roberts M.S., Barnard R.T. Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles. Magnes Res. 2016;29:35-42.
  • [5] Wang H., Meng F. The permeability enhancing mechanism of menthol on skin lipids: a molecular dynamics simulation study. J Mol Model. 2017;23:279.
  • [6] Joshi A., Joshi A., Patel H., Ponnoth D., Stagni G. Cutaneous penetration-enhancing effect of menthol: calcium involvement. J Pharm Sci. 2017;106:1923-1932.
  • [7] Franz T.J. Percutaneous absorption on the relevance of data. J Invest Dermatol. 1975;64:190-195. in vitro
  • [8] Workinger J.L., Doyle R.P., Bortz J. Challenges in the diagnosis of magnesium status. Nutrients. 2018;10:1202.
  • [9] Commission regulation (EU) No 432/2012. (accessed 25 Oct. 2019).
  • [10] Abd E., Yousef S.A., Pastore M.N. Skin models for the testing of transdermal drugs. Clin Pharmacol. 2016;8:163-176.
  • [11] Roy S.D., Flynn G.L. Transdermal delivery of narcotic analgesics: pH, anatomical and subject influences on cutaneous permeability of fentanyl and sufentanil. Pharm Res. 1990;7:842-847.
  • [12] Roy S.D., Roos E., Sharma K. Transdermal delivery of buprenorphine through cadaver skin. J Pharm Sci. 1994;83:126-130.
  • [13] Mayuramas S., Byoung Y., Mazen H., Chee C.L., Rosanoff A., Mahavir C. Preliminary study of transdermal permeation of magnesium cream formulations across skin. Magnes Res. 2012;25:203-204.
  • [14] Gröber U., Werner T., Vormann J., Kisters K. Myth or reality–transdermal magnesium? Nutrients. 2017;9:813.
  • [15] Proksch E., Nissen H.P., Bremgartner M., Urquhart C. Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin. Int J Dermatol. 2005;44:151-157.
  • [16] Koppes S.A., Charles F., Lammers L., Frings-Dresen M., Kezic S., Rustemeyer T. Efficacy of a cream containing ceramides and magnesium in the treatment of mild to moderate atopic dermatitis: a randomized, double-blind, emollient- and hydrocortisone-controlled trial. Acta Derm Venereol. 2016;96:948-953.
  • [17] Bromm B., Scharein E., Darsow U., Ring J. Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett. 1995;187:157-160.
  • [18] Craighead D.H., Alexander L.M. Topical menthol increases cutaneous blood flow. Microvasc Res. 2016;107:39-45.
  • [19] Juergens U.R., Stöber M., Vetter H. The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes : a novel perspective for its therapeutic use in inflammatory diseases. Eur J Med Res. 1998;3:539-545. in vitro
  • [20] Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev. 2003;24:47-66.