Cellular metabolic pathways and influenza viruses: the great hijacking Volume 15, issue 1, Mars 2011


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Université de Lyon, Université Claude Bernard Lyon I - Hospices civils de Lyon, Laboratoire de Virologie et Pathologie Humaine (VirPath), Faculté de médecine RTH-Laennec, rue Guillaume-Paradin, 69372 Lyon Cedex 08, France, Groupement hospitalier Est, Hôspices civils de Lyon, Centre de biologie et pathologie Est, Laboratoire de virologie, 59, boulevard Pinel, 69677 Bron Cedex, France, Centre National de Référence des virus influenza, Région Sud, Lyon

Influenza A viruses express up to 12 proteins and consequently depend on the host cellular machinery for their replication. During the last years, high throughput methods for screening and analysis allowed to improve the characterization of cellular metabolic pathways and their constitutive factors interacting with viral replication. This review presents the data relative to the main cellular signaling cascades (induced or altered during infection) and the host key factors that are functionally involved in different steps of viral replication. This contribution of fundamental knowledge in cellular biology of influenza will be discussed in the perspective of the development of new classes of broad-spectrum antivirals that will target key cellular factors rather than viral components.