La famille des protéines IFITM : effets antiviraux et fonctions cellulaires Volume 19, issue 6, Novembre-Décembre 2015


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1 Institut Pasteur,
Virology Department,
Virus and Immunity Unit,
28, rue du Docteur-Roux,
75724 Paris cedex 15, France
2 CNRS, URA3015, Paris, France
3 École polytechnique,
Université Paris-Saclay,
* Tirés à part

The interferon-induced transmembrane (IFITM) proteins restrict the entry of diverse viruses into the host cell, and as such form an important part of the cell-intrinsic innate immune response. Their broad-spectrum activity makes them particularly interesting in the context of the fight between host and pathogens. They act in part by altering the properties of cellular membranes, which blocks the early event of virus-cell fusion. Furthermore, in the case of HIV, IFITM proteins decrease the infectivity of virions produced from infected cells. As a result of their remarkable potential as antiviral inhibitors, the structure, subcellular localisation, and post-translational modification of IFITM proteins have been the subject of active research. In this review, we summarize the different properties ascribed to this dynamic protein family and provide a framework to reveal novel functions in the presence or absence of virus infection.