JLE

Sang Thrombose Vaisseaux

MENU

Medical management of the metabolic syndrome Volume 18, issue 10, Décembre 2006

Authors
Service d’endocrinologie-métabolisme, hôpital de la Pitié-Salpêtrière, 75651 Paris cedex 13

The metabolic syndrome is an association of glucose and lipid abnormalities with abdominal obesity with an increased risk of developing diabetes and cardiovascular diseases. Poor diet and a sedentary life style are the main etiological factors in genetically predisposed persons. Individualised management is based on diet and physical exercise as there is no pharmacological treatment for this syndrome as such. Lipid lowering drugs, oral antidiabetic agents and antihypertensive therapy are available for treating cach component of the syndrome: statins are the drugs of choice for lipid abnormalities even in cases with hypertriglyceridaemia; rennin-angiotensin-aldosterone system inhibitors and calcium antagonists are the preferred options for treating hypertension. In all cases, pharmacological intervention should be considered as adjuvant therapy to changes in life style, the central pillar of management of the metabolic syndrome.