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Post natal follow-up of antenatal multicystic renal dysplasia Volume 12, issue 2, avril-mai-juin 2010
- Key words: HNFI-beta, renal cyst, chronic renal disease, hypertension, genital malformation, nephroprotection
- DOI : 10.1684/mte.2010.0282
- Page(s) : 100-2
- Published in: 2010
Unilateral multicystic dysplastic kidney is the most drastic anomaly of the metanephros development. The frequency of the disease has been estimated at 1/4,300 live births. The main concerns of this disease are the follow-up of the involution of the cystic structure and the development of a compensatory hypertrophy of the contralateral kidney, the risk of a contralateral urinary tract malformation and an ipsilateral genital malformation in male as well as in female, the risk of a nephron reduction with hypertension and the progression to chronic renal failure, the risk of an association to a mutation in the HNF1-β gene. The risk to develop a neoplasy in the cystic structure is likely to be similar to those of the general population. The post natal follow-up has to deal with these different issues and to select patients that will need long term follow-up at adult age.