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Journal de Pharmacie Clinique

Recent advances in the treatment of hypotension Volume 21, issue 2, Juin 2002

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  • Author(s): V. MAYNIAL, S. JORON , Service pharmacie, Centre hospitalier de Calais, 11, quai du commerce, BP 339, 62107 Calais cedex, France.
  • Key words: postural hypotension, autonomic dysfonction, treatment.
  • Page(s) : 104-8
  • Published in: 2002

Postural hypotension is defined as a fall in blood pressure of over 20 mmHg systolic or 10 mmHg diastolic on head-up postural change. It may be a presenting feature in primary or in secondary neurogenic failure. The therapeutic strategie includes both non-pharmacological and pharmacological measures. The goal of treatment is to obtain a target blood pressure and an improvement of patient's functional capacity. A large selection of pharmacological agents allows to stabilize the disease process in autonomic disorders such as midodrine, fludrocortisone... The management of orthostatic hypotension is dependent upon an individual approach.