John Libbey Eurotext

Journal de Pharmacie Clinique


Hyperosmolar coma and protease inhibitors Volume 17, issue 3, Septembre 1998

  • Key words: hyperosmolar coma, protease inhibitors.
  • Page(s) : 178-9
  • Published in: 1998

Protease inhibitors can disturb glycemia. We report the case of a 39 years old man drug user, HIV and VHC positive, treated for two months with an antiretroviral quadruple oral therapy drug user with stavudine, lamivudine, ritonavir and saquinavir. He was admitted to the clinical haematology department for a chemotherapy cure to treat a Hodgkin’s disease but the day following his admission, he went in a stage II hyperosmolar coma. Protease inhibitors have been incriminated with the corticosteroids. These treatments have been stopped, which allowed the patient to recover clear consciousness.