CHRU de Lille, Université Lille 2, service d’hépato-gastroentérologie, France
Unité Inserm U995, Université Lille 2, France
Université de Lille, Inserm, Institut de Pathologie CHU Lille, UMR-S 1172 - JPARC - Jean-Pierre Aubert Research Center, F-59000 Lille, France
Recent epidemiologic data estimate that fatty liver affects around 25% of adults and 17% of adolescents and children. The rise of this disease is strongly linked to the increase of obesity and its metabolic consequences. Fatty liver will become a purpose for medical consultation for the specialist as well as for the general practitioner. Identification of severe forms of fatty liver (NASH) is warranted and requires histological proof. However, the extension of liver biopsy to the entire population is impossible. Thus, radiologic and biological non-invasive biomarkers are needed to stratify the risk and select a population that will require a liver biopsy. This review details the different histological scores used in non-alcoholic fatty liver disease as the Brunt, Kleiner and SAF score. The main biomarkers available, their use for diagnosis and follow up are summarized to help the clinician.