Hôpital Archet 2,
service d’hépato-gastroentérologie, de nutrition clinique et de cancérologie digestive,
151 Route Saint Antoine de Ginestière,
06202 Nice Cedex 3,
Université de Nice Sophia Antipolis,
service d’immunologie et EA 6302 Tolérance immunitaire,
The irritable bowel syndrome (IBS) affects approximately 4.7% of the general French population, 1/3 having predominance of constipation (IBS-C). The diagnosis of IBS is based on the Rome III criteria, a stool diary using bristol scale allowing at best the separation between IBS subtypes. A more profound alteration of quality of life has been demonstrated in patients having IBS-C compared with those having chronic constipation without IBS. The complexity of mechanisms to explain IBS symptoms have lead to the notion of bidirectionnel brain-gut alterations, some of which being more frequent in some IBS phenotypes. This review shows the current knowledge on pathophysiological mechanisms involved in IBS, in particular patients having IBS with predominance of constipation.