John Libbey Eurotext

Hépato-Gastro & Oncologie Digestive


Unmet needs in Ulcerative Colitis Volume 27, supplement 4, Novembre 2020


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CHU de Bordeaux, Hôpital Haut-Lévêque, Centre Médico-chirurgical Magellan, service d’hépato-gastroentérologie, 33600 Pessac ; INSERM CIC 1401, Bordeaux
* Correspondance

The number of medical options to treat patients with Ulcerative Colitis (UC) has dramatically increased during the last decades. However, a wide proportion of patients are still not able to recover normal life. Patients’ expectations from medical treatment are a rapid symptoms relief with a low side effects risk. On the other side, gastroenterologists target deep and sustained remission. This discrepancy can impact patients’ adherence to therapy. Therapeutic education can help reduce this communication gap and improve quality of life.

Medical management of refractory UC has dramatically improved within the last period leading to decreasing number of colectomy. However, in some specific situations like proctitis or acute severe UC clinical benefits of the medical treatment remains limited. Overall, one out of six UC patients needs colectomy within the ten years after diagnosis. Finally, patients who are not operated are exposed to a higher colorectal cancer risk than general population and to infectious and oncological risks of the prolonged use of immunosuppressants. Research efforts should be directed for covering these unmet needs in UC.