Allergologue libéral, 28 rue de Ponthieu, 75008 Paris, France
Food allergy may affect the gastrointestinal tract or have an extra-digestive expression. The manifestations of allergy affect the gastro-intestinal tract with disorders of variable gravity. The knowledge of the multiple clinical presentations of food allergy will prompt the gastroenterologist to search for other elements to confirm the allergic etiology. The diagnosis is based on a compatible clinical history, in conjunction with the demonstration of an IgE mediated sensitization by skin prick tests and/or the determination of specific anti-food IgE. The diagnosis of food allergy manifestations of a non-IgE-dependent mechanism is based on clinical arguments supported by typical histological lesions of the gastro-intestinal mucosa. The blinded oral challenge test is the gold-standard diagnostic test for IgE-dependent allergies and some non-IgE-dependent food allergies. In no case, the diagnosis of allergy can be based on the biological results alone. The anti-food IgG assay is not recommended for the diagnosis of food allergy or intolerance.
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