Hépato-Gastro & Oncologie Digestive
MENUHER2+ gastroesophageal adenocarcinomas: Current standards and therapeutic perspectives Volume 29, issue 4, April 2022
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Institut de Cancérologie de Montpellier (ICM), Département d’Oncologie Médicale, Univ. Montpellier, Montpellier, 208 Avenue des Apothicaires, Parc Euromédecine, 34298 Montpellier Cedex 5
* Correspondance : S. Quesada
- Key words: gastroesophageal adenocarcinomas, HER-2, trastuzumab, trastuzumab deruxtecan, immune checkpoint inhibitors, targeted therapies
- DOI : 10.1684/hpg.2022.2359
- Page(s) : 507-13
- Published in: 2022
Esogastric adenocarcinomas (EGA) are characterized in 10-20 of cases by overexpression and/or amplification of HER-2. Current standard treatment for HER2+ EGA relies on trastuzumab (an anti-HER-2 antibody) plus a doublet of chemotherapy (fluoropyrimidine + platinum salt). For more than a decade, no obvious therapeutic progress has enriched the therapeutic arsenal for these patients, whether in the first-line with other anti-HER2 agents or in the context of trastuzumab resistance. The first results of studies based on trastuzumab-deruxtecan and immune checkpoint inhibitors are therefore likely to modify management practices for HER2+ AOG.