Hépato-Gastro & Oncologie Digestive


Spur cells and cirrhosis Volume 30, issue 2, February 2023


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1 CHU de Lille, Hôpital Claude Huriez, Pôle médico-chirurgical Huriez, Service des maladies de l’appareil digestif, 59037 Lille Cedex
2 CHU de Lille, Centre de biologie pathologie Pierre-Marie Degand, Laboratoire d’hématologie, Lille
* Correspondance : M. Pahul

The causes of anemia in cirrhosis are multiple and interrelated. Among the corpuscular anomalies, acanthocytosis is the most frequently erythrocytic deformation found, mainly in cases of severe decompensation. It is responsible for hemolytic anemia by destruction of red blood cells and splenic sequestration of deformed erythrocytes. Its presence correlates with the severity of cirrhosis and is associated with significant short-term mortality. Liver transplantation is the only treatment allowing the disappearance of acanthocytosis and the improvement of the prognosis of these patients.