UMR 6543 CNRS-UNSA, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice cedex 02.
Angiogenesis is a multistep process inducing formation of new blood vessels, mediated by angiogenic molecules released by tumors cells themselves. In contrast to solid tumors, few data are available regarding angiogenesis in hematologic malignancies. In this review we have set out to examine the recent data about angiogenesis in hematology. However there is evidence in the litterature which suggests that increased angiogenesis in hematologic malignancies does occur. Tumors cells promote angiogenesis principally throught production of the angiogenic factor VEGF (vascular endothelial growth factor). In light of recent observations in our laboratory, the role and mechanisms controlling expression of VEGF in the realm at hematology will be discussed.