John Libbey Eurotext



Familial Chronic lymphoid leukemia (CLL): state of the art Volume 18, issue 3, Mai-Juin 2012


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Hôpital de la Pitié-Salpêtrière 47, bd de l’hôpital, 75013 Paris

Chronic lymphocytic leukemias represent the most frequent familial hemopathies. First degree related of a patient with a CLL have a risk of lymphoid hemopathy increased by 8,5. These families are mostly composed of only CLL and/or monoclonal lymphocytosis of undetermined significance (“pure” families) and, in 40 % of cases, of CLL and other lymphoid malignancies (“mixt” families), this repartition is inverted for other familial lymphoid hemopathies. At the moment of diagnosis, familial CLL have usually good prognosis criteria: Binet stage A, CD38+, mutated IgVH, negative ZAP70, del(13q)… No gene has been identified to date, either by candidate gene research, comparative genomic hybridization or genome wide association studies.