Hôpital de la Pitié-Salpêtrière
47, bd de l’hôpital,
Chronic lymphocytic leukemias represent the most frequent familial hemopathies. First degree related of a patient with a CLL have a risk of lymphoid hemopathy increased by 8,5. These families are mostly composed of only CLL and/or monoclonal lymphocytosis of undetermined significance (“pure” families) and, in 40 % of cases, of CLL and other lymphoid malignancies (“mixt” families), this repartition is inverted for other familial lymphoid hemopathies. At the moment of diagnosis, familial CLL have usually good prognosis criteria: Binet stage A, CD38+, mutated IgVH, negative ZAP70, del(13q)… No gene has been identified to date, either by candidate gene research, comparative genomic hybridization or genome wide association studies.