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Pharmacological inhibition of the NF-κB signaling pathway Volume 12, issue 1, Janvier-Février 2006

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Authors
Inserm U697, Pavillon Bazin, Hôpital Saint-Louis, Paris, Unité REAC, Institut Pasteur, Paris
  • Key words: NF-κB, IKK, inflammation, cancer, inhibitors
  • Page(s) : 50-60
  • Published in: 2006

The NF-κB signaling pathway plays a crucial rôle in inflammation, immune response and cell cycle control. It therefore represents a major therapeutic target to treat diseases associated with inflammation, autoimmunity or cancer. Here, we present the various inhibitors of NF-κB that have been recently identified or designed and examine the putative advantages and pitfalls they may exhibit when used in the clinic.