Inserm U697, Pavillon Bazin, Hôpital Saint-Louis, Paris, Unité REAC, Institut Pasteur, Paris
- Key words: NF-κB, IKK, inflammation, cancer, inhibitors
- Page(s) : 50-60
- Published in: 2006
The NF-κB signaling pathway plays a crucial rôle in inflammation, immune response and cell cycle control. It therefore represents a major therapeutic target to treat diseases associated with inflammation, autoimmunity or cancer. Here, we present the various inhibitors of NF-κB that have been recently identified or designed and examine the putative advantages and pitfalls they may exhibit when used in the clinic.