John Libbey Eurotext



Prognostic factors of monoclonal gammopathy of undetermined significance Volume 14, issue 3, Juillet 2008

Service de médecine interne, Hôpital Sud, 16 boulevard de Bulgarie, 35056 Rennes Cedex, Laboratoire d’hématologie, Institut de biologie, 9 quai Moncousu, 44093 Nantes

Monoclonal gammopathy of undetermined significance (MGUS) is found in 3,4 % of the general population over 50 years. The frequence increase with age. MGUS is a pre malignant state. Malignant transformation risk is about 1 % per year. Some predictive factors of malignant transformation have been identified : type of serum monoclonal protein, monoclonal protein concentration, elevation of monoclonal protein concentration during first years of follow-up, bone marrow plasmocytosis, serum free light chain ratio, bone marrow aberrant plasma cells percentage, aneuploidy, circulating plasmocytosis… Predictive scores combining these factors have been recently proposed and allow identifying groups of patients with significantly differents rates of transformation. These scores require validation. These scores will probably allow individual monitoring of patients.