John Libbey Eurotext

Hématologie

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Emergence of anti-angiogenic therapy : strategies and perspective in cancer Volume 4, issue 4, Juillet-Août 1998

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Treating cancer by targeting its vasculature is a recent conceptual revolution. It is now widely recognized that solid primary or disseminated tumor growth, as well as the process of blood vessel-mediated metastasis depend on the development of intra- and peri-tumoral vasculature. The rapid advance in the understanding of the process of vasculogenesis and angiogenesis has promoted the identification of a series of molecules that form a network controlling the formation, maturation and remodeling of vascular system. The use of newly discovered potent anti-angiogenic factors has confirmed the anti-growth and anti-metastatic efficiency of anti-angiogenic therapy in a variety of experimental solid tumor models. In addition, it appeared that such therapy with endostatin did not induce drug resistance allowing a repetitive long-term treatment. This review summarizes the biological basis of this new therapy, including antiangiogenic gene therapy, which open promising perspectives in cancer treatment.