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Epileptic Disorders

The Educational Journal of the International League Against Epilepsy

Upward gaze and head deviation with frontal eye field stimulation Volume 14, issue 1, March 2012


  • Upward gaze and head deviation with frontal eye field stimulation


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Epilepsy Center, Department of Neurology, University Hospitals Case Medical Center, Department of Neurological Surgery, University Hospitals Case Medical Center, Daroff-Dell’Osso Ocular Motility Laboratory, Louis Stokes Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio
  • Key words: brain mapping, eye movement, frontal eye field
  • DOI : 10.1684/epd.2012.0494
  • Page(s) : 64-8
  • Published in: 2012

Using electrical stimulation to the deep, most caudal part of the right frontal eye field (FEF), we demonstrate a novel pattern of vertical (upward) eye movement that was previously only thought possible by stimulating both frontal eye fields simultaneously. If stimulation was started when the subject looked laterally, the initial eye movement was back to the midline, followed by upward deviation. Our finding challenges current view of topological organisation in the human FEF and may have general implications for concepts of topological organisation of the motor cortex, since sustained stimulation also induced upward head movements as a component of the vertical gaze shift. [ Published with video sequences]