John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

The natural history of nodding syndrome Volume 20, issue 6, December 2018

Figures

  • Figure 1

Tables

Authors
1 Makerere University College of Health Sciences, Uganda
2 Centre for Tropical Neuroscience, Kitgum Site, Uganda
3 Nuffield Department of Medicine, University of Oxford, UK
4 Busitema University, Uganda
5 Gulu Regional Referral hospital, Uganda
6 Ministry of Health, Headquarters, Uganda
* Correspondence: Richard Idro Makerere University College of Health Sciences, P.O Box 7072, Kampala, Uganda
  • Key words: head nodding, neuro-inflammation, head drops, atonic seizures, Onchocerca volvulus
  • DOI : 10.1684/epd.2018.1012
  • Page(s) : 508-16
  • Published in: 2018

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Aims

Nodding syndrome is a poorly understood acquired disorder affecting children in sub-Saharan Africa. The aetiology and pathogenesis are unknown, and no specific treatment is available. Affected children have a distinctive feature (repeated clusters of head nodding) and progressively develop many other features. In an earlier pilot study, we proposed a five-level clinical staging system. The present study aimed to describe the early features and natural history of nodding syndrome and refine the proposed clinical stages.