John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

The efficacy of bromides, stiripentol and levetiracetam in two patients with malignant migrating partial seizures in infancy Volume 13, issue 1, Mars 2011

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  • The efficacy of bromides, stiripentol and levetiracetam in two patients with malignant migrating partial seizures in infancy

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Authors
University of Belgrade, Mother and Child Health Care Institute “Dr. Vukan Cupic” Belgrade, Serbia
  • Key words: migrating partial seizures, bromide, stiripentol, levetiracetam, therapeutic effect, refractory epilepsy
  • DOI : 10.1684/epd.2011.0402
  • Page(s) : 22-6
  • Published in: 2011

The syndrome of malignant migrating partial seizures in infancy is a devastating, age-specific, epileptic encephalopathy, which still presents an aetiological, pathophysiological and therapeutic problem. In this study, we present two patients who were diagnosed with the disease, based on electroclinical symptoms. The patients were treated with a combination of sodium bromide, stiripentol and levetiracetam. The first patient unequivocally responded, following a course of ineffective conventional drugs, and the second, who was diagnosed and treated immediately, showed a more significant therapeutic response. Antiepileptic drugs, previously reported to be beneficial in case reports, when given concomitantly, may substantially reduce the number and severity of seizures, without influence on psychomotor development. [Published with video sequences]