John Libbey Eurotext

Nocturnal interictal epileptic discharges in adult Lennox-Gastaut syndrome: the effect of sleep stage and time of night Volume 18, issue 1, March 2016


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1 Institutions de Lavigny, Service d’épileptologie, Lavigny, Switzerland
2 Service de physiologie clinique et de l’exercice, Pole NOL, CHU, Faculté de médecine J. Lisfranc, UJM et PRES Université de Lyon, Saint-Étienne, France
* Correspondence: Emilia Sforza Service d’épileptologie, Institutions de Lavigny, Route du Vignoble, 1175 Lavigny, Switzerland


Lennox-Gastaut syndrome (LGS) is characterized by interictal epileptiform discharges (IEDs) occurring during sleep. The aim of this study was to determine whether sleep influences not only the frequency of seizures and IEDs, but also the time-dependent evolution that may support the hypothesis of homeostatic influences on epileptic threshold.