John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

Epileptology of the first tonic-clonic seizure in adults and prediction of seizure recurrence Volume 20, issue 6, December 2018


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Department of Clinical Neurophysiology and Epilepsy, Guy's & St Thomas’ NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK
* Correspondence: Michalis Koutroumanidis Department of Clinical Neurophysiology and Epilepsy and Department of Neurology, Guy's & St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, UK
  • Key words: incident epilepsy, epilepsy classification, sleep deprivation, sleep EEG, risk factors
  • DOI : 10.1684/epd.2018.1014
  • Page(s) : 490-501
  • Published in: 2018


The risk of seizure recurrence after a first unprovoked seizure is influenced by certain risk factors. To understand their effect in people with early diagnosed new epilepsy, we assessed the risk of recurrence of focal to bilateral tonic-clonic or generalized tonic-clonic seizures and the associated factors in a clinically well-characterized cohort of adults with a first unprovoked tonic-clonic seizure.