John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

EEG of asymptomatic first-degree relatives of patients with juvenile myoclonic, childhood absence and rolandic epilepsy: a systematic review and meta-analysis Volume 21, issue 1, February 2019


1 Program in Genetics and Genome Biology, The Hospital for Sick Children, Institute of Medical Science, University of Toronto, Toronto
2 Paediatric Neurology Division, Department of Paediatrics, King Abdullah Specialist Children Hospital, Riyadh
3 Knowledge translation program, Li Ka Shing Knowledge Institute of St Michael's hospital, Epidemiology division, Dalla Lana school of public health, University of Toronto, Canada
4 Johns’ Hopkins Aramco Healthcare, Dhahran, Saudi Arabia
5 Division of Neurology, Department of Pediatrics, University of Texas Southwestern, Dallas, USA
* Correspondence: Berge Minassian University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas TX 75390, USA
  • Key words: Rolandic epilepsy, childhood absence epilepsy, juvenile myoclonic epilepsy, endophenotype, EEG trait, spike wave, sibling, unaffected
  • DOI : 10.1684/epd.2019.1024
  • Page(s) : 30-41
  • Published in: 2019


Rolandic (RE), childhood absence (CAE) and juvenile myoclonic (JME) epilepsy encompass centrotemporal sharp waves, 3-Hz spike waves and >3-Hz spike or polyspike waves, respectively. Evidence abounds for genetic roles in all three syndromes, yet involved genes for the vast majority of patients remain unknown. It has long been proposed that while each disease is genetically complex, its specific EEG trait may represent a genetically simpler endophenotype. This meta-analysis of the literature focuses on the frequency of EEG traits in clinically unaffected first-degree relatives towards determining inheritance patterns of the EEG endophenotypes.