Epileptic Disorders


Diagnosing Lennox-Gastaut syndrome in an adult and its direct impact in epilepsy care Volume 24, issue 4, August 2022


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1 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
2 Department of Neurology, Saint Louis University, Saint Louis, MO, USA
Fábio Augusto Nascimento e Silva
55 Fruit St., Wang 7th floor, Boston, MA 02114, USA

We report a 34-year-old male with intellectual disability and refractory, childhood-onset, non-lesional epilepsy featuring absence, generalized tonicclonic, and tonic seizures leading to falls. Seizure onset occurred at the age of 11 years, and tonic seizures did not appear until he was an adult. Notably, tonic seizures were mostly during sleep. Physical examination did not show dermatologic or ophthalmologic abnormalities. Current antiseizure drugs include zonisamide and cenobamate, and he underwent [...]

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