John Libbey Eurotext

Antiepileptic effect of olanzapine in epilepsy patients with atypical depressive comorbidity Volume 20, issue 3, June 2018


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1 Department of Neurology, West China Hospital, Sichuan University, No. 37 Guo Xue Road, Chengdu, Sichuan, 610041, China
2 Centro de neurociências aplicadas (CeNAp), Universidade Federal de Santa Catarina (UFSC), Hospital Governador Celso Ramos (HGCR), Florianópolis, SC, Brazil
3 Medical Sciences Post-graduate Program, Universidade Federal de Santa Catarina, (UFSC), Florianópolis, SC, Brazil
4 Danish Epilepsy Centre, Dianalund, Denmark
* Correspondence: Lei Chen Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan Province, 610041, China
  • Key words: epilepsy, depression, bipolar disorder, interictal dysphoric disorder, olanzapine
  • DOI : 10.1684/epd.2018.0977
  • Page(s) : 225-31
  • Published in: 2018

Depression is relatively common among patients with epilepsy, but often with predominant atypical symptoms. Some antiepileptic drugs show positive psychotropic effects, but these are not always sufficient to stabilize mood in epilepsy patients. Antidepressants are recommended to treat atypical depression but are not always effective and present a certain risk of seizure provocation. Thus, new treatment options are welcome. Here, we describe three cases of refractory epilepsy with atypical depression in which olanzapine, contrary to its earlier reported proconvulsant effect, showed excellent antidepressant action and resulted in seizure control. Possible mechanisms of this action are discussed.