John Libbey Eurotext

Absence of increased blood decanoic acid levels in children with epilepsy treated with classic ketogenic diet Volume 21, issue 4, August 2019


1 Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, Paris
2 AP-HP, Hôpital Robert Debré, Service de Neurologie Pédiatrique, Paris
3 AP-HP, Hôpital Robert Debré, Service de Biochimie, Paris, France
* Correspondence: Stéphane Auvin Service de neurologie pédiatrique et des maladies métaboliques, CHU Hôpital Robert Debré, 48, boulevard Sérurier, 75935 Paris cedex 19, France


Recently, decanoic acid (C10), a medium-chain fatty acid, was shown to be a direct inhibitor of the AMPA receptor. Accordingly, C10 has been suggested as a potential anticonvulsant factor in the ketogenic diet (KD) or the medium-chain triglyceride KD. Here, we tested whether C10 serum levels correlate with the response to KD in five children (1.5 ± 0.6 years of age) with epilepsy.