John Libbey Eurotext

European Journal of Dermatology


Virginal breast hypertrophy: clinicopathological similarities between virginal breast hypertrophy and diffuse dermal angiomatosis of the breast Volume 28, issue 4, July-August 2018


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1 Department of Dermatology, Venereology, Allergology, Medical University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria
2 Dermatohistological laboratory and private practice, Postfach 4145, 90021 Nürnberg, Germany

Virginal breast hypertrophy (VBH) is a disorder characterized by a massive (uni- or bilateral) increase in breast size and bears no apparent correlation with the growth of other body parts [1]. It is a rare disease with rapid development of macromastia, usually at the onset of thelarche or later on. The pathogenesis and aetiology of VBH are still poorly understood. Hypotheses range from hormonal imbalance, genetic predisposition (reported cases of PTEN gene mutation) [1, 2], to a drug-induced disorder [...]