John Libbey Eurotext

European Journal of Dermatology


The influence of sun exposure on the DNA methylation status of MMP9, miR-137, KRT14 and KRT19 genes in human skinDNA methylation and sun exposure Volume 25, issue 5, September-October 2015


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1 Programa de Pós Graduação em Biologia Celular e Molecular,
2 Departamento de Biologia Molecular,
Centro de Ciências Exatas e da Natureza,
Universidade Federal da Paraíba,
João Pessoa, PB-Brazil
3 Departamento de Morfologia,
Centro de Ciências da Saúde,
Universidade Federal da Paraíba,
João Pessoa, PB-Brazil
* Reprints
a These authors contributed equally to the study.
  • Key words: epigenetic, DNA methylation, sun, MMP, microRNA, skin, keratin
  • DOI : 10.1684/ejd.2015.2598
  • Page(s) : 436-43
  • Published in: 2015

The effect of solar radiation is one of the greatest human concerns. Chronic exposure over many years can change the normal architecture of the dermis and epidermis causing premature aging (photoaging) [1] and skin cancer [2]. It is the most common form of cancer in the United States and Brazil, with a worldwide increasing incidence [3, 4].It is well established that solar UV radiation can cause mutations in DNA and increase the risk of developing skin cancer [5]. However, little is known about the [...]